Potentially, this is a game where the goals could really flow.
Both teams had a very good midweek result. Tottenham's win over Liverpool was their second on the bounce after three successive defeats, so they have turned the corner again. Fulham's draw at Chelsea was largely overlooked as the spotlight inevitably fell on Rafa Benitez and the Blues' shortcomings, but for the visitors it was an impressive performance.
Though both capital clubs are in relatively good shape, the form book favours the north-east Londoners - Spurs have won the last five Premier League meetings, although Fulham did beat them 4-0 at Craven Cottage in the 2011 FA Cup fourth round.
I covered Tottenham's victory at Craven Cottage last season, a 3-1 November win when Harry Redknapp was in hospital recovering from heart surgery. Spurs were playing some of their best football for years, and even being talked of as potential title contenders. But their season somewhat fell away soon after. Much has changed since then, of course.
Spurs will have to pay attention to old favourite Dimitar Berbatov. In two seasons at Spurs he scored 46 goals in all competitions and he has not lost against his former club in six outings since leaving. He's also scored 23 goals in his last 27 Premier League starts. His class remains.
On the other hand, Clint Dempsey - now with Spurs but Fulham's record Premier League goal-scorer - has been a little rueful about the circumstances in which he left; he will be desperate to make a mark. This is also Mousa Dembele's first return to Craven Cottage. The match will have a special meaning for all three players.
It will also make Martin Jol's heart beat a little quicker. He took Tottenham to fifth place on two occasions when he was in charge at White Hart Lane, and remains something of a cult hero with the fans there.
With a host of attacking players to the fore, a goalless draw is unlikely - especially when you consider the number of high-scoring games both clubs have been involved in this season. Allied to that, Spurs have only kept one clean sheet in 14 Premier League games so far.
Head-to-head
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Tottenham have won the last five Premier League matches between the two clubs.
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Fulham last won at home to Spurs in the league in November 2008, triumphing 2-1 (Harry Redknapp's first loss as a Tottenham boss).
Fulham
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They have not won for six Premier League games (D4, L2).
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Fulham's starting line-up against Chelsea had an average age of 32 years and 32 days, the oldest of any Premier League club for almost three years since Portsmouth in March 2010.
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They have lost 50 of 101 London derbies in the Premier League.
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Dimitar Berbatov is unbeaten in all six Premier League matches against Tottenham since leaving the club (four wins). He has scored once (in Manchester United's 5-2 home victory in April 2009).
Tottenham
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Spurs have conceded in each of their last seven Premier League matches, and kept only one clean sheet all season.
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Gareth Bale has been booked three times for simulation since the start of last season - more than any other player in the Premier League during that period.
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Tottenham have made more defensive clearances (645) than any other team in the Premier League this season.
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Midfielder Tom Huddlestone will be hoping to make his 100th Premier League start for Tottenham.
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Clint Dempsey scored 58 league goals for Fulham between 2007-12, making him the club's record Premier League goalscorer. Mousa Dembele made 62 Premier League appearances for Fulham between 2010-12, scoring five goals.