League One leaders travel across London aiming to cause an FA Cup upset against Premier League rivals Fulham.
Chris Powell's men will be backed by over 7,000 fans when they visit Craven Cottage for the third-round clash on Saturday afternoon.
The Addicks have not visited their West London rivals in over five years - when they were still a Premier League side.
A lot has changed at The Valley since then with the feel-good factor returning this season as Powell's new-look squad have opened up a five-point lead at the top of League One.
However, Powell concedes the Cottagers will be a different proposition and has admitted this week that he would be happy to return home with a draw.
Fulham have continued to make waves in the top-flight and European competition since Charlton's relegation, but they have been hindered by inconsistency this season.
However, they head into the tie buoyed by Monday's superb 2-1 home win over Arsenal and will be aiming to dish out more capital punishment by beating Charlton.
Head-to-head
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There is only one win between these clubs after 64 competitive meetings since 1929; Fulham have won 22, Charlton 21, with 21 drawn.
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are crossing swords for the first time since December 2006 in the Premier League, when Fulham extended their undefeated run over the Addicks to five games.
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Charlton have progressed three times and Fulham twice after being paired together five times previously in the FA Cup, but the Cottagers enjoyed success most recently; 3-0 at Craven Cottage in their fourth round in January 2003.
Fulham
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Fulham embark on their 36th match of the season, and on a home tie in the FA Cup for the sixth time in seven occasions, and the fourth in a row.
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They were last knocked out in the third round in January 2008, when League One Bristol Rovers defeated them courtesy of a penalty shoot-out.
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The 1975 runners-up, have reached at least the fifth round in each of the last three seasons.
Charlton
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1946 runners-up and 1947 winners Charlton have only qualified for the fourth round in one of the last five seasons.
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The Addicks were a second level club when they last dumped out a Premier League outfit; Coventry, 3-2 away in the fifth round in January 2000.
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Chris Powell's side are involved in one of two London derbies in this third round, and are yet to concede a goal on this season's FA Cup run.