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Fulham will be without the services of Calvin Bassey, who was sent off against Arsenal on Saturday.
Willian is also a doubt due to a muscular problem, with the Brazilian unlikely to be risked, but Tim Ream will be back from a suspension of his own and should start.
Head coach Silva Marco Silva will undoubtedly make changes to his starting side for this match, with Tom Cairney, Harrison Reed, Adama Traore, Kevin Mbabu and Marek Rodak among those likely to come into the XI.
Raul Jimenez was impressive against Arsenal on Saturday, but Carlos Vinicius is expected to come into the side to lead the line against Tottenham on Tuesday.
Fulham possible starting lineup:
Rodak; Mbabu, Adarabioyo, Ream, Robinson; Reed, Lukic; Traore, Cairney, Wilson; Vinicius
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Spurs will again be without the services of Tanguy Ndombele, Rodrigo Bentancur, Ryan Sessegnon, Bryan Gil and Alfie Whiteman through injury; Destiny Udogie is also a doubt due to a knock.
Head coach Postecoglou will also shuffle his pack for this match, with Ivan Perisic, Oliver Skipp, Ben Davies, Emerson Royal and Davinson Sanchez set to come into the side.
Fraser Forster is expected to get the nod between the sticks, while there could be starts for Pierre-Emile Hojbjerg and Giovani Lo Celso despite the speculation surrounding their futures.
Tottenham Hotspur
possible starting lineup:
Forster; Emerson, Sanchez, Van de Ven, Davies; Hojbjerg, Skipp, Lo Celso; Perisic, Richarlison, Solomon
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