Fulham, made the expected sweeping changes from their midweek FA Cup third-round replay win over Norwich, have never won in any competition at Arsenal, and have now lost 23 of their visits to north London.
The Cottagers remain in deep trouble just a point out of the relegation zone after the 2-0 defeat.
However Fulham manager Rene Meulensteen remains optimistic.
He said: "I couldn't have asked for anything more at half-time. We knew it would be even harder in the second half because of the quality of players they have.
"If you switch off for one moment they can hurt you, an that's what they did, but there were lots of positives to take from it from our point of view.
"You must always see the results and the performances, they are interlinked.
"Our performances have been really good, but (we) haven't had the results."
Meulensteen, who took over from Martin Jol in December, added: "I think we can survive, definitely. The spirit is good, we have got plenty of quality, and I believe the short time I have been in with these players we are improving all the time, working hard.
"What we need is a break with a run of results, but that's not easy because of the opponents we are facing."