Fulham have had an indifferent start to the season in the Championship, but have won two out of the last three league games and a win in their game in hand could propel them up towards the play-off places.
The Cottagers easily overcame last year's semi-finalists Sheffield United in the previous round and will hope home advantage could play a part in their bid for victory over their Premier League opponents.
Stoke head to Craven Cottage positioned in the Premier League relegation zone and looking for a morale-boosting win against Championship side Fulham in the Capital One Cup third round tie.
Despite an encouraging performance in the first half against Leicester at the weekend, Mark Hughes' team threw away a two-goal lead to draw 2-2 which would have been their first league win this season.
The Potters' only win this season was in the previous round where they needed penalties to overcome League Two side Luton Town. Assistant coach, Mark Bowen, has warned there can be no room for complacency as Stoke travel to London.
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Fulham have won eight of their last nine games at home against Stoke, including the last four.
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These two sides met in the third round in 2010-11, with Stoke running out 2-0 winners.
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Fulham have reached the fourth round of the Capital One Cup in the last two seasons.
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The Cottagers have won three of their last four games in all competitions, scoring 10 goals.
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Ross McCormack has scored four goals in the last three games, scoring 52 goals since the start of 2013-14, including 47 in Championship.
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This is Fulham's first League Cup game against a side from a higher division since the quarter-final in 2000-01 when they were beaten by Liverpool.
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Fulham have won 40%, drawn 25% and lost 35% of their last 20 home games.
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Mark Hughes was a League Cup winner with three different clubs as a player - 1992 with Man Utd, 1998 with Chelsea and 2002 with Blackburn.
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Stoke's three points from their opening six games is their worst top flight start since 1983-84.
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Since Stoke were promoted to the Premier League in 2008, they've only failed to reach the fourth round once, when they were knocked out in the second round in 2012-13 by Swindon.
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The Potters are unbeaten in four away League Cup games, winning two in normal time and two on penalties.
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Stoke have kept a clean sheet in 3 of their last 20 away games, going on to win 2 and draw 1 of these matches.
Source SkySports/BBCSports/KickOff.