Other than overcoming Wycombe Wanderers in the first round of this competition, Fulham are yet to taste victory in the Championship in Kit Symons' first full campaign at the helm.
After holding Cardiff City on the opening weekend, the Cottagers suffered consecutive 2-1 defeats to Brighton & Hove Albion and Hull City.
However, Cauley Woodrow's stoppage-time equaliser rescued them a point against Huddersfield Town on Saturday and that will give them something to build on this evening.
Although, they will be hoping to avoid another surprise defeat like they suffered the last time United visited here in the 2014 FA Cup third-round replay.
Sheffield United arrive at Craven Cottage for their Capital One Cup clash against Fulham on the back of four straight wins.
Following their 4-0 thumping at Gillingham on the opening day in League One, Nigel Adkins' men kick-started their campaign with a 1-0 win over Morecambe in the first round before seeing off Chesterfield, Peterborough United and Blackpool.
They reached the semi-finals of this competition last season, eventually losing to Tottenham Hotspur, and an equally impressive run would be very welcome for the Blades.
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Sheffield United have won seven and drawn three of 10 FA and League Cup matches against Fulham.
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The Blades' last trip to Craven Cottage saw them score a 120th minute winner in an FA Cup replay (February 2014).
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Fulham have scored in each of their last 22 home League Cup games, averaging 2.68 goals per game.
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Fulham's only defeat to a lower-ranked side in the League Cup at Craven Cottage since 1990 came against Wycombe in 2006, with the Whites winning their other 10 home ties in this period.
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Fulham have kept a clean sheet in 4 of their last 20 home games, going on to win 4 and draw 0 of these matches.
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Fulham have scored 1 goal or less in 11 of their last 20 home games, going on to win 1, draw 3 and lose 7 of these matches.
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In their last 20 home games, 23 of the 33 goals scored by Fulham have come from forwards, 6 from midfielders and 4 from defenders.
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In their last 20 home games, 70% of the 33 goals scored by Fulham have come in open play, whilst 30% have come from set-pieces.
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Fulham have conceded in 80% of their last 20 home games.
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Fulham last kept a clean sheet at home 9 games ago.
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Sheff Utd have kept a clean sheet in 4 of their last 20 away games, going on to win 4 and draw 0 of these matches.
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Sheff Utd have scored 1 goal or less in 12 of their last 20 away games, going on to win 2, draw 5 and lose 5 of these matches.
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In their last 20 away games, 88% of the 26 goals scored by Sheff Utd have come in open play, whilst 12% have come from set-pieces.
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Sheff Utd have conceded in 80% of their last 20 away games.
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In their last 20 away games, Sheff Utd have scored the first goal 9 times and conceded the first goal 11 times.
Source Jonny Davies at footballleagueworld/BBCSports/KickOff