Arsenal wrap up their season against a Fulham side readying themselves for a European final.
The Gunners will be disappointed to be ending another campaign empty-handed, with their free-flowing football yet to produce the desired results.
They have rather stumbled towards the finish as well, securing only one win in five and losing three of their last four.
Arsene Wenger's men have also won just two of their last seven London derbies at Emirates Stadium, which does not bode well.
On a more positive note, the Gunners have never lost to Fulham on home soil in a Premier League encounter, taking six wins and two draws from their eight meetings to date.
Arsenal will also take heart from the fact that they have won all seven of their Premier League home dates on the final day of the season.
Fulham will be hoping to buck that trend this year, with the Cottagers having kept five clean sheets in their last seven final day fixtures.
They have never drawn their last game of the season during the Premier League era, while Arsenal have only been held once.
Worryingly for Roy Hodgson's side, they have won none of their last 29 local derbies away from home.
The Cottagers may be prepared to accept seeing that run extended this weekend, as their priorities lie elsewhere.
They are preparing for a meeting with Atletico Madrid in the Europa League final next Wednesday and may take this opportunity to rest a number of their key men - especially as their request to have the game moved to Saturday was knocked back by the Premier League.
Left-back Gael Clichy could be available again for Arsenal as they look to finish with a flourish.
France international Clichy may make his return from an ankle problem, while Robin van Persie and Andrey Arshavin should start, but Tomas Rosicky (ankle), Alex Song (knee) and Nicklas Bendtner (groin) are still out.
Cesc Fabregas (knee), William Gallas (calf), Thomas Vermaelen (calf), Denilson (groin), goalkeeper Manuel Almunia (wrist) and Aaron Ramsey (leg) remain sidelined.
Fulham are unlikely to risk Bobby Zamora in a game with nothing resting on it.
Source SkySports