Tottenham extended their unbeaten run, in all competitions, to 10 games with a 2-0 victory over Newcastle on Tuesday, and are now in fourth place.
They are now just five points behind leaders Manchester United and another victory would put pressure on their rivals.
Fulham, meanwhile, are in the relegation zone despite their 2-0 win at Stoke in midweek.
The win was rare; it was their first away from home in 27 attempts, going back to the start of last season.
But their record at White Hart Lane is poor. In a total of 31 league visits, they have won just twice, in the Premier League in September 2002, and in the old Second Division in April 1948. Spurs have won 17 and drawn 12.
Spurs, though, will be without Jermain Defoe, serving the second game of a three match ban, and Younes Kaboul, who is suspended following his 'stupid' red card in the 2-0 win over Newcastle.
William Gallas could return if passed fit from a hamstring problem, but Tom Huddlestone, Ledley King, Jamie O'Hara and Jonathan Woodgate are all still missing.
Fulham recalled Chris Baird at Stoke and he responded with two early goals in the 2-0 win over the Potters, so he should keep his place ahead of the dropped Carlos Salcido.
This season: Fulham 1 Tottenham 2.
Last season: Fulham 0 Tottenham 0, Tottenham 2 Fulham 0.
Stat of the game: Fulham have failed to score in five of their last six league visits to White Hart Lane.
Referee: Mike Jones. Matches: 14. R1 Y50.
Source John Ley at Daily Telegraph