Fulham manager Roy Hodgson's chances of overcoming Alberto Zaccheroni's side in the Europa League have been boosted by the news that Juventus will be without their first and second-choice goalkeepers Gianluigi Buffon and Alex Manninger.
Veteran stopper Antonio Chimenti is likely to step in for the Bianconeri but Hodgson has to contend with selection problems of his own.
Captain Danny Murphy and fellow midfielder Jonathan Greening are suspended while Andy Johnson, John Pantsil (both knee) and David Elm (illness) are all injured.
Hodgson is relishing the opportunity of taking the Cottagers to a new high in their history.
"I think it's fairly obvious that if we were able to knock out a team like Juventus it would be a massive achievement, especially given the circumstances that we are facing in that we are missing quite a few players," the 62-year-old said.
"I'm sure that it would be a massive feather in Fulham's cap."
Doubts remain whether Chimenti, 39, will be able to cope with the pressure of playing in such a fixture after he let in three goals in Juve's 3-3 draw with Serie A's bottom side Siena on Sunday.
Hodgson, who has had three spells managing in Italy, has no doubts about the stopper's ability though.
"I would think he's played more European games than (Fulham keeper) Mark Schwarzer and has played many games in Serie A so I don't see that as being a particular weakness," the former Inter Milan boss said.