Fulham have won just six times in 25 league visits to Manchester City.
And they face a City side that has kept 12 clean sheets in this season's Premier League, the joint highest, with Chelsea.
The visitors have drawn 13 games, the most in the Premier League.
Indeed, manager Mark Hughes, who left Eastlands in December 2009, has drawn 20 of his last 38 games with both his former and present clubs.
Fulham arrive unbeaten in three but having drawn their last two, Chelsea and Villa.
City have won just one of their last four Premier League games, against West Brom, but when they went to Craven Cottage in November they left with a 4-1 win.
Carlos Tévez, Yaya Toure and Pablo Zabaleta gave City a three-goal advantage by the 35th minute. Tévez scored again before Zoltan Gera claimed a consolation goal for Fulham.
But Fulham's recent record at City is impressive with three wins, three draws and only two defeats in eight Premier League visits.
Last season, when Hughes was manager of City, Fulham came back from a two-goal deficit to claim a draw thanks to a 68th minute equaliser from Clint Dempsey.
City are still without Adam Johnson (ankle) and Nigel de Jong (ankle) while Shay Given has been ruled out for the season with a shoulder problem.
Fulham could consider giving Bobby Zamora his first start since he broke his leg against Wolves in September though he may have to be content with a place on the substitute's bench.
Some facts and figures ahead of the Premier League match between Manchester City and Fulham at The City of Manchester Stadium.
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Manchester City have won only one of their last seven Premier League home games against Fulham.
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Both teams have scored in the last 13 Premier League games between Manchester City and Fulham.
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10 of the last 11 Premier League clashes between City and Fulham have gone over 2.5 goals.
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Carlos Tevez has scored six goals in City's last five Premier League games.
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Five of City's last six goals have come in the first half.
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Fulham have scored only two first half goals in eight Premier League games in 2011.
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The Cottagers have conceded just five goals in the Premier League in 2011; no side have let in fewer.
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Fulham's Moussa Dembélé has committed 38 fouls in the league without being booked this term; more than any other player.
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Man City have played just 58.6% of their passes into, or in, the opposition half this season; a lower ratio than any other Premier League side.
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Fulham have netted just 9.8% of their shots this term; fewer than all other top-flight sides.
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This season: Fulham 1 City 4.
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Last season: City 2 Fulham 2, Fulham 1 City 2.