Arsenal moving 13 points ahead of the Man Utd by hammering Leeds 5-0 on Friday night. The Gunners can prepare to uncork the championship champagne after awesome Henry became the first Arsenal player in 13 years to hit four goals in a game as United were humiliated at Highbury.
Wenger's men demolished their relegation-haunted opponents 5-0 to pile up a 13-point cushion at the top-flight summit and stretch their record-breaking unbeaten league run to 33 games.
Manchester City were edged closer to the relegation zone by a 3-1 defeat at home to Southampton on a day when attention shifted to the painful end of the Barclaycard Premiership table.
With Blackburn and Portsmouth both winning, City - who welcomed Kevin Keegan back to the dug-out after a four-match absence with a back complaint - emerged as the side the bottom three will hope to catch.
James Beattie put the Saints in front after 34 minutes, the England international heading home a cross from Marian Pahars, who was newly returned to the line-up after two months out injured.
And the visitors doubled their lead 10 minutes into the second half when Kevin Phillips headed in. Nicolas Anelka pulled a goal back after 78 minutes but Phillips netted his second to restore Southampton's two-goal lead.
Basement side Wolves, who started the day nine points from safety, proved they were still alive and kicking as they beat Middlesbrough 2-0.
Carl Cort put them ahead in the 28th minute, heading in Mark Clyde's cross from the right and Henri Camara netted a second after 62 minutes. Middlesbrough have designs on Europe but the defeat could have been more convincing as Mark Schwarzer saved a late penalty from Camara.
Leicester were plunged deeper into the relegation mire as nervy Blackburn dragged themselves away from the drop zone with a precious victory.
It took an own goal from City defender Nikos Dabizas to hand Rovers only the fourth home win of a disappointing Barclaycard Premiership campaign, but it was perhaps the most valuable yet.
Manchester United all but said goodbye to their title after they went down 1-0 at Portsmouth in an early kick-off at Fratton Park.Sir Alex Ferguson's side looked very far from the Gunners' class as they failed to keep pace with their rivals.
Veteran midfielder Steve Stone, 33, scrambled home the only goal of the game to earn Portsmouth their first win over United in 47 years.
The result opened the door for Chelsea to buttress their claims to second place which offers an automatic Champions League slot rather than the possibility of a qualifying tie.
But Claudio Ranieri's side, England's sole surviving Champions League representatives this season, could take no immediate advantage as they were held to a goalless draw by Everton despite dominating the second half.
Steven Gerrard does not deserve to be branded as the player who cost Liverpool their Champions League dream.
But his missed spot kick early in the second half - Michael Owen clearly not keen on the duties anymore - will go down as one of the darkest moments of his and Liverpool's season.
It was the one lifeline they should not have spurned as the battled to overcome a defiant Fulham who stopped Gerard Houllier's men in their tracks much the same way as Charlton had done on Easter Monday.
It has left Liverpool with just one point from their last three games and Anfield gripped in misery and condemnation.
However, Birmingham and Charlton - two other sides with ambitions to play in Europe's premier club competition - played out a 1-1 draw at the Valley.
Clinton Morrison gave the visitors an 84th-minute lead but Matt Holland equalised for Charlton two minutes later.
Ivan Campo swept home Jay-Jay Okocha's cross to give Bolton a seventh-minute lead over Tottenham which was doubled by Henrik Pedersen in the 65th minute in the only Premiership game to have little riding on the outcome.
Ten-man Newcastle weathered a storm for 81 minutes to secure a goalless draw at Aston Villa but the result did little for either side's Champions League ambitions. Andy O'Brien was sent off for a clumsy challenge on Darius Vassell as he bore down on goal inside 10 minutes and from that point on the visitors were always on the back foot.
The closest Villa came to scoring was in first-half injury-time when Vassell had the ball in the net only the effort to be rather harshly disallowed for a foul on Aaron Hughes. A win would have put either side into the coveted fourth place in the Premiership but the draw only extended Newcastle's abysmal run of 11 away matches without a win.