The Carling Cup second round draw threw up the prospect of more giant-killing exploits after most of the Barclays Premiership clubs were paired with League Two opposition.
Fulham will be happy with their home draw to Wycombe Wanderers as the Wanderers have won just one of their encounters with the Cottagers. The last time the two squads clashed was in January 2002 when Fulham won 1-0 in an FA Cup replay.
Wycombe's teenage goalkeeper Ricardo Batista will be looking forward to the game, more than most, as he on a 5 month loan at Wycombe from Fulham.
Accrington Stanley's reward for knocking out double European champions Nottingham Forest on their first ever appearance in the competition is a trip to Watford, while the Football League's bottom club Bury - who shocked Sunderland in round one - visit the Hornets' fellow top-flight new boys Sheffield United.
Wigan, Everton, Bolton, Manchester City, Aston Villa and Portsmouth all face potential banana skins after they were drawn away from home.
City face arguably the toughest task with a trip to League One Chesterfield but the others will also need to be careful.
Everton are up against Peterborough, Bolton travel to Walsall, Villa are at Scunthorpe, Portsmouth tackle Mansfield and last year's runners-up Wigan take on Crewe.
Of the remaining four Premiership sides to be drawn at home, Fulham face Wycombe, Charlton host Carlisle, Reading welcome Darlington and Middlesbrough meet Notts County - who beat Crystal Palace at Selhurst Park in the first round.
The two sides relegated from the top flight last season still in the competition have both have been drawn at home, with West Brom hosting Cheltenham and Birmingham playing Wrexham.
Carling Cup second round draw:
Fulham v Wycombe
Leeds v Barnet
Watford v Accrington Stanley
Crewe v Wigan
Doncaster v Derby
Sheff Utd v Bury
Millwall v Southampton
West Brom v Cheltenham
Peterborough v Everton
Hereford v Leicester
Port Vale v QPR
Hull v Hartlepool
Walsall v Bolton
Middlesbrough v Notts County
Charlton v Carlisle
Barnsley v M K Dons
Chesterfield v Man City
Scunthorpe v Aston Villa
Southend v Brighton
Brentford v Luton
Reading v Darlington
Birmingham v Wrexham
Rotherham v Norwich
Mansfield v Portsmouth
Ties to be played over the week commencing September 18.